Farsite 2022

Farsite 2022

About FARSITE

NWEH uniquely offers a data-enabled protocol design, site feasibility, recruitment and follow up service with a globally leading and proven track record. At the centre of this offering is FARSITE: Feasibility Assessment and Recruitment System for Improving Trial Efficiency. FARSITE is an established feasibility tool to search, find, and recruit participants from primary care settings into clinical trials, whilst still preserving their confidentiality. Our ground-breaking technology is backed up and utilised by a holistic and experienced community-based research team. These expert clinicians work with primary care physician investigators to ensure rapid recruitment, low screen failure rates, and excellent long-term retention. Our community team works closely with these physicians at primary care sites or, if necessary, in a domiciliary capacity.

Our unique technology, currently deployed over the Greater Manchester and North West London geographies, permits rapid and accurate protocol design based on up-to-date information from electronic health record (EHR) systems. Protocol design and feasibility that traditionally may have taken weeks to months can now be achieved in hours or days. In addition, by working with our primary care centres and physicians we can rapidly validate the search criteria in a few centres to ensure that, once deployed at scale, recruitment proceeds as anticipated.

Challenge

A significant problem faced by potential trial sponsors is not being able to find enough eligible patients to make their trial a reality. Pinpointing eligible patients can be expensive, time consuming, difficult, and frustrating.


Part of this issue is knowing how to design a protocol which will yield the greatest number of eligible patients while still conforming to clinical parameters. FARSITE offers the unique ability to quickly & cost effectively ‘test’ the protocol design and refine it to deliver optimum results. This offers a more diverse and accurate list of eligible patients who are very likely to be more representative of the population at large

Solution

  • Research ready sites: We have a pool of research active primary care sites with whom we have worked previously. We have agreements to search across a total population of approximately 5.7 million patients at 322 practices
  • FARSITE Feasibility: Researchers see how many patients match a trial protocol; the number of patients matching each criterion; and the patient’s practice. When the researcher is ready to recruit for a trial, they use FARSITE to contact relevant GP practices
  • Streamlined recruitment: FARSITE includes built in tools to streamline patient invitations so that participating GPs have a minimal workload when inviting potential participants.
    • Classic Study: We achieved a 30% patient conversion rate by recruiting 4400 patients in under 16 weeks, with a 70% practice conversion rate: 33 of our 47 selected practices took part
    • Spirit Study: We achieved a 37% patient conversion rate.
  • Study Implementation: Our research team supports participating centres by the provision of clinical services for consent, biological sampling and any other protocol related activities


Benefits

A suite of technical solutions designed to accelerate end-to-end clinical processes and improve trial efficiency

  • Accurate data: Find the right patients in near real time using data direct from the Electronic Healthcare Record (EHR). Our unique EHR data linkage means low screen failure and more successful follow up rates, with only 2 out of 7200 patients lost in follow up for the Salford Lung Studies.
  • Recruit more diverse patients: Using real world data gives the opportunity recruit a more representative range of participants.
  • Near real-time search provides answers to trial design questions and finds participants quickly.
  • Flexible, secure and easy-to-use: authorised clinicians or researchers can use natural language terms to rapidly design trials and select potential primary care sites. Patient details are anonymised to researchers and only identifiable to primary care clinicians (i.e. Data Controllers).
  • The service is led by a team of subject matter experts with over a decade of experience in conducting technology-enabled trial designs, recruiting over 15000 participants from primary care sites into clinical trials in the Greater Manchester region alone in multiple disease areas, including respiratory conditions, diabetes, cardiovascular disease and Covid-19.
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